Located about a 5-minute stroll from the Salita Mandrella, the 3-star smoke-free Hotel Sereno Sestri Levante features Wi-Fi in public areas and street parking on site. There is a train station near this Sestri Levante hotel, and guests can easily reach the Via XXV Aprile which is only 150 metres away.

The centre of Sestri Levante is a 10 minutes' walk of the hotel. Natural attractions in the area include the Nelson Mandela Park, within a few blocks of the Sereno Sestri Levante, and a beach is nearly a 10-minute stroll away. Also, Parco Mandela is situated just 0.8 km away. There is the Riva Ponente approximately a 25-minute walk away.

The air-conditioned rooms comprise a patio and a terrace, and offer wireless internet and a flat-screen TV with satellite channels along with a mini-fridge-bar. The rooms have modern furniture featuring a writing desk. Providing a bidet, a separate toilet, and a shower, the bathrooms are also appointed with a hairdryer and shower caps.

Drinks are available at the lounge bar. The bar area includes a lounge. While staying at Hotel Sereno, guests can choose from dining options nearby, such as Ristorante sapore di mare, located only 50 metres away, or I Due Forni Pizzeria at a 6-minute walking distance.