The 3-star Leone X Genova Hotel provides proximity to the National Ligurian Gallery at Palazzo Spinola, which is located only 1.5 km away.

The centre of Genoa can be reached within a 15-minute walk, and natural attractions like the Villetta Di Negro are about a 5-minute ride away. This Genoa hotel is stationed 2.3 km from the Museum of Sant'Agostino. Guests might as well visit Giardini Achille Pellizzari, which is approximately a 5-minute drive away. Also, the Palazzo Bianco lies only 1.4 km away, while De Ferrari underground station is within a few blocks of the Leone X Genova. The nearest bus stop is Portello / Caffaro, located merely a 5-minute stroll away, and Genova Brignole train station is nearly a 20-minute walk away.

Only 1.1 km from the hotel, Pizzeria Lupin serves Italian meals.